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| Extraction and Crystal Structure of Physalin B |
| YANG Yan-Jun;SHA Cong-Wei;CHEN Mei-Guo;HU Ling |
a (Guangdong Institute of Chinese Materia Medica, Guangdong Food and Drug Vocational College, Guangzhou 510520, China)
b (Guangdong Provincial Institute of Biological Products and Materia Medica, Guangzhou 510440, China)
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Abstract The title compound of physalin B (C28H32O9), a main active physalin of Physalis angulata L, was isolated from the whole plant of Physalis angulataL, and characterized by X-ray diffraction analysis. It crystallizes in the monoclinic system, space group P21 with C28H32O9, α = 12.4996(2), b = 14.35620(10), c = 14.75190(10) Å, V = 2607.97(5) Å3, Z = 4, Dc = 1.382 mg/cm3, Mr = 542.56, F(000) = 1152, andμ = 0.870 mm-1. The final R = 0.0389 and wR = 0.1037 for 47670 observed reflections (I > 2σ(I)). The rigid molecule consists of eight fused rings involving two lactones. There are two C28H32O9 molecules in an symmetric unit, and the title compound is stacked into a 3D layer structure through hydrogen bonds. In the 5～20 μmol/L range, physalin B can significantly inhibit the secretion of inflammatory cytokines TNF-α and IL-6 on RAW264.7 cells. The results suggest that physalin B has anti-inflammatory activity in vitro.
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Received: 26 July 2013
Published: 12 May 2014
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| Fund:Supported by the Guangdong Provincial Science and Technology Projects (No. 2011B031700072), and Guangdong Natural Science Foundation (No.9151063201000036,S2013010013484), Guangdong Provincial Administration of traditional Chinese medicine project (No. 2008435) |
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Corresponding Authors:
杨燕军: ncyyj@163.com
E-mail: ncyyj@163.com
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| About author:: 杨燕军: ncyyj@163.com |
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2014, Vol. 33 
