Syntheses, Crystal Structures and in vitro Anticancer Activities of Dibenzyltin Compounds Based on the N-(2-Phenylacetic acid)-aroyl Hydrazone

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Abstract Two dibenzyltin compounds, {[C6H5O(O)C=N–N=C(Ph)COO] (m-Cl–C6H4CH2)2- Sn(CH3OH)}2 (1) and {[p-Me–C6H4O(O)C=N–N=C(Ph)COO] (m-Cl–C6H4CH2)2Sn(CH3OH)}2 (2), have been synthesized by microwave “one pot” reaction with benzoylhydrazine (or p-methyl benzhydrazine), phenylglyoxylic acid and di-m-chlorobenzyltin dichloride. Compound 2 contains two crystals 2a and 2b. The compounds have been characterized with IR, elemental analysis, 1H, 13C and 119Sn NMR spectra, H RMS. Three crystals are all binuclear molecules with a Sn2O2 four-membered ring plane, and each Sn atom center is seven-coordinated with [SnO4C2N] to form a distorted pentagonal bipyramidal configuration. In vitro antitumor activities of all compounds and carboplatin were evaluated by MTT against three human cancer cells such as NCI-H460 (lung cancer cells), HepG2 (liver cancer cells) and MCF7 (breast cancer cells), and compound 2 exhibited better antitumor activity.

Key words： organotin complex hydrazine synthesis crystal structure biological activity

Received: 08 July 2019 Published: 13 April 2020

Fund:The project was supported by the Hengyang Normal University College Students Innovation and Entrepreneurship Training Program (No. cxcy1944), Scientific Research Fund of Hunan Provincial Education Department of China (No. 19C0279), Hengyang Normal University Industrial Supported Project (Nos. HXKJ201907, HXKJ201908, HXKJ201911, HXKJ201946, HXKJ201947), and Foundation of Key Laboratory of Functional Organometallic Materials, University of Hunan Province (No. GN19K07)

Corresponding Authors: tanyuxing@hynu.edu.cn E-mail: tanyuxing@hynu.edu.cn

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	JIANG Wu-Jiu
	MO Tian-Zi
	ZHANG Fu-Xing
	KUANG Dai-Zhi
	TAN Yu-Xing

Cite this article:

JIANG Wu-Jiu,MO Tian-Zi,ZHANG Fu-Xing, et al. Syntheses, Crystal Structures and in vitro Anticancer Activities of Dibenzyltin Compounds Based on the N-(2-Phenylacetic acid)-aroyl Hydrazone[J]. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2020, 39(4): 673-681.

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http://manu30.magtech.com.cn/jghx/EN/ OR http://manu30.magtech.com.cn/jghx/EN/Y2020/V39/I4/673

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