Advances in Structure-function Relationships and Mechanism of Transporter Associated with Antigen Processing
潘显超;梅虎;王青;张亚兰;谭文;晁丽
1. 重庆大学生物流变科学与技术教育部重点实验室2. 重庆大学生物工程学院
Advances in Structure-function Relationships and Mechanism of Transporter Associated with Antigen Processing
PAN Xian-Chao;MEI Hu;WANG Qing;ZHANG Ya-Lan;TAN Wen;CHAO Li
a. Key Laboratory of Biorheological Science and Technology (Ministry of Education), Chongqing University, Chongqing 400044, Chinab. College of Bioengineering, Chongqing University, Chongqing 400044, China
摘要The transporter associated with antigen processing (TAP) belongs to the ATP-binding cassette (ABC) transporter superfamily. Driven by ATP hydrolysis, TAP translo- cates antigenic peptides from the cytosol into the ER (endoplasmic reticulum) lumen where the antigenic peptides are loaded onto the HLA class I molecules. Recently, numerous studies show that TAP is closely related with various diseases such as viral infections, autoimmune diseases, and different malignancies.In consideration of important roles of TAP in human adaptive immunity, this review summarizes the recent advances in structure-function relationships of crucial domains and transport mechanism systematically. The challenging problems and potential methods are also pointed out for in-depth researches.
Abstract：The transporter associated with antigen processing (TAP) belongs to the ATP-binding cassette (ABC) transporter superfamily. Driven by ATP hydrolysis, TAP translo- cates antigenic peptides from the cytosol into the ER (endoplasmic reticulum) lumen where the antigenic peptides are loaded onto the HLA class I molecules. Recently, numerous studies show that TAP is closely related with various diseases such as viral infections, autoimmune diseases, and different malignancies.In consideration of important roles of TAP in human adaptive immunity, this review summarizes the recent advances in structure-function relationships of crucial domains and transport mechanism systematically. The challenging problems and potential methods are also pointed out for in-depth researches.
潘显超;梅虎;王青;张亚兰;谭文;晁丽. Advances in Structure-function Relationships and Mechanism of Transporter Associated with Antigen Processing[J]. , 2013, 32(4): 475-488.
PAN Xian-Chao;MEI Hu;WANG Qing;ZHANG Ya-Lan;TAN Wen;CHAO Li. Advances in Structure-function Relationships and Mechanism of Transporter Associated with Antigen Processing. , 2013, 32(4): 475-488.
2013, Vol. 32 
