Exploration of a Library of Triazolothiadiazines as Potent Plant Growth Promoters: Design, Synthesis, X-ray Diffraction Analysis and Bioactivity Studies
丁其春;蔡艺敏;王司雷;姚培炮;杨儒雅
Department of Pharmacy, Zhangzhou Health Vocational College, Zhangzhou 363000, China
Exploration of a Library of Triazolothiadiazines as Potent Plant Growth Promoters: Design, Synthesis, X-ray Diffraction Analysis and Bioactivity Studies
A series of novel 3-methyl-6-aryl-7-aroyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were designed, synthesized and tested for their antiproliferative activity against HepG2 cell lines in vitro by the standard SRB assay and plant growth regulation activities on wheat (amonocotyledon) and radish (adicotyledon). The results indicated all the title compounds exhibited a very weak antiproliferative activity against HepG2 cell lines in vitro unexpectedly, while showed potent plant growth-regulating activities on both wheat and radish. The crystal structure of trans-4d was obtained from X-ray diffraction: C18H13N4OSCl3, Mr = 439.75, monoclinic system, space group P21/n, a = 5.3224(7), b = 14.3578(18), c = 24.442(3) Å, β = 94.180(2)°, V = 1862.8(4) Å3, F(000) = 899, Z = 4, Dc = 1.5679 g/cm3, λ = 0.71073 Å, μ = 0.621 mm 1 and the final R = 0.0382 for 3274 unique reflections with 2851 observed ones (I > 2σ(I)).
A series of novel 3-methyl-6-aryl-7-aroyl-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were designed, synthesized and tested for their antiproliferative activity against HepG2 cell lines in vitro by the standard SRB assay and plant growth regulation activities on wheat (amonocotyledon) and radish (adicotyledon). The results indicated all the title compounds exhibited a very weak antiproliferative activity against HepG2 cell lines in vitro unexpectedly, while showed potent plant growth-regulating activities on both wheat and radish. The crystal structure of trans-4d was obtained from X-ray diffraction: C18H13N4OSCl3, Mr = 439.75, monoclinic system, space group P21/n, a = 5.3224(7), b = 14.3578(18), c = 24.442(3) Å, β = 94.180(2)°, V = 1862.8(4) Å3, F(000) = 899, Z = 4, Dc = 1.5679 g/cm3, λ = 0.71073 Å, μ = 0.621 mm 1 and the final R = 0.0382 for 3274 unique reflections with 2851 observed ones (I > 2σ(I)).
基金资助: This work was supported by the Education Research Project of Fujian Province, China (No. JZ180850)
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引用本文:
丁其春;蔡艺敏;王司雷;姚培炮;杨儒雅. Exploration of a Library of Triazolothiadiazines as Potent Plant Growth Promoters: Design, Synthesis, X-ray Diffraction Analysis and Bioactivity Studies[J]. 结构化学, 2021, 40(8): 1098-1106.
DING Qi-Chun;CAI Yi-Min;WANG Si-Lei;YAO Pei-Pao;YANG Ru-Ya . Exploration of a Library of Triazolothiadiazines as Potent Plant Growth Promoters: Design, Synthesis, X-ray Diffraction Analysis and Bioactivity Studies. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2021, 40(8): 1098-1106.
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