Two Cu(II) and Co(II)-based Coordination Polymers Based on the N,S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation

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摘要 Two new Cu(II) and Co(II)-based coordination polymers with the chemical formulae of {Cu(L)2]·DMF}n (1) and {[Co(L)2]·2DMF}n (2) have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand, namely [3,4΄-bipyridine]-2΄-thiol (HL). Complex 1 is composed of two identical coordination networks with dia topology interpenetrating into each other, and shows 1-D microporous channels along the a axis. Complex 2 is assembled by 2-D square-grid layers stacked in an eclipsed fashion to give 1-D large square channels along the b axis. CCK-8 was used for the detection of cancer cells. Results indicated that compound 1 exhibited stronger anti-cancer activity than compound 2 on the H1650 cancer cells. The Annexin V-FITC/PI was recommended for cancer cell apoptosis, and the western blot was applied for the detection of PI3K/AKT pathway activation.

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	李靖
	李江涛

关键词 ： coordination polymer, N,S-donor ligand, CCK-8 assay, anticancer activity

Abstract：Two new Cu(II) and Co(II)-based coordination polymers with the chemical formulae of {Cu(L)2]·DMF}n (1) and {[Co(L)2]·2DMF}n (2) have been successfully constructed from a pyridine-substituted N-heterocyclic thioamide ligand, namely [3,4΄-bipyridine]-2΄-thiol (HL). Complex 1 is composed of two identical coordination networks with dia topology interpenetrating into each other, and shows 1-D microporous channels along the a axis. Complex 2 is assembled by 2-D square-grid layers stacked in an eclipsed fashion to give 1-D large square channels along the b axis. CCK-8 was used for the detection of cancer cells. Results indicated that compound 1 exhibited stronger anti-cancer activity than compound 2 on the H1650 cancer cells. The Annexin V-FITC/PI was recommended for cancer cell apoptosis, and the western blot was applied for the detection of PI3K/AKT pathway activation.

Key words： coordination polymer N,S-donor ligand CCK-8 assay anticancer activity

收稿日期: 2019-04-18 出版日期: 2020-10-10

基金资助:This project was supported by the Industrial Research Project of Science and Technology, Department of Shaanxi Province (No. 2017GY-126)

通讯作者: lijiangtao-968@xawl.edu.cn E-mail: lijiangtao-968@xawl.edu.cn

引用本文:

李靖;李江涛. Two Cu(II) and Co(II)-based Coordination Polymers Based on the N,S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation[J]. 结构化学, 2020, 39(10): 1849-1854.
LI Jing;LI Jiang-Tao. Two Cu(II) and Co(II)-based Coordination Polymers Based on the N,S-donor Ligand: Crystal Structures and Anticancer Activity Evaluation. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2020, 39(10): 1849-1854.

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http://manu30.magtech.com.cn/jghx/CN/ 或 http://manu30.magtech.com.cn/jghx/CN/Y2020/V39/I10/1849

REFERENCES
(1) Novio, F.; Simmchen, J.; Vázquez-Mera, N.; Amorín-Ferré, L.; Ruiz-Molina, D. Coordination polymer nanoparticles in medicine. Coord. Chem. Rev. 2013, 257, 2839–2847.
(2) Lian, H. Y.; Hu, M.; Liu, C. H.; Yamauchi, Y.; Wu, K. C. W. Highly biocompatible, hollow coordination polymer nanoparticles as cisplatin carriers for efficient intracellular drug delivery. Chem. Commun. 2012, 48, 5151–5153.
(3) Li, F.; Li, T.; Cao, W.; Wang, L.; Xu, H. Near-infrared light stimuli-responsive synergistic therapy nanoplatforms based on the coordination of tellurium-containing block polymer and cisplatin for cancer treatment. Biomaterials 2017, 133, 208–218.
(4) Abu-Surrah, A.; Kettunen, M. Platinum group antitumor chemistry: design and development of new anticancer drugs complementary to cisplatin. Curr. Med. Chem. 2006, 13, 1337–1357.
(5) Muhammad, N.; Guo, Z. Metal-based anticancer chemotherapeutic agents. Curr. Opin. Chem. Biol. 2014, 19, 144–153.
(6) Jin, L. N.; Liu, Q.; Sun, W. Y. An introduction to synthesis and application of nanoscale metal-carboxylate coordination polymers. CrystEngComm. 2014, 16, 3816–3828.
(7) Zhang, J. P.; Huang, X. C.; Chen, X. M. Supramolecular isomerism in coordination polymers. Chem. Soc. Rev. 2009, 38, 2385–2396.
(8) Abbasi, Z.; Salehi, M.; Khaleghian, A.; Kubicki, M. Co(III), V(IV) and Cu(II) complexes of bidentate N,O-donor Schiff base ligands: characterization, anticancer activities and metal oxide nanoparticles preparation via solid state thermal decomposition. Appl. Organomet. Chem. 2018, 32, e4542.
(9) Gao, E.; Xing, J.; Qu, Y.; Qiu, X.; Zhu, M. Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of Cu(II) and Mn(II) complexes with 1,4-bis (pyrazol-1-yl) terephthalic acid. Appl. Organomet. Chem. 2018, 32, e4469.
(10) Wang, T.; Chen, Y.; Nie, H.; Huang, Y.; Zhao, Y.; Yang, J. IL-27 inhibits non-small-cell lung cancer cell metastasis by miR-935 in vitro. Onco. Targets. Ther. 2019, 12, 1447–1454.
(11) Wang, H.; Lou, C.; Ma, N. miR-140-5p alleviates the aggressive progression of Wilms' tumor through directly targeting TGFBR1 gene. Cancer Manag. Res. 2019, 11, 1641–1651.
(12) Sun, B.; Dong, C.; Lei, H.; Gong, Y.; Li, M.; Zhang, Y.; Zhang, H.; Sun, L. Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem. Biol. Interact. 2018, 294, 28–33.