Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo[d]imidazol-2-yl)benzenesulfonamide Derivatives of Dehydroabietic Acid

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摘要 The title compounds (7a～7g) were synthesized from dehydroabietic acid and characterized by spectroscopic methods including HR-MS, 1H- and 13C-NMR. The crystal structure of compound 7g determined by single-crystal X-ray diffractio is of monoclinic system, space group P21 with a = 12.282(3), b = 9.940(2), c = 22.656(5) Å, β = 103.06(3)°, Z = 2, V = 2694.4(10) Å3, Mr = 1182.95, Dc = 1.458 Mg/m3, S = 1.000, μ = 1.649 mm-1, F(000) = 1216, the final R = 0.0791 and wR = 0.1853 for 4098 observed reflections (I > 2σ(I)). The preliminary antibacterial assay showed that compound 7g exhibits significant inhibitory against Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant S. aureus (MRSA) with MIC values of 1.9～7.8 μg/mL.

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	蔡旭敏
	李阿良
	蔺玉婷
	王文燕
	王石发
	谷文

关键词 ： dehydroabietic acid, benzimidazole, sulfonamide, crystal structure, antibacterial activity

Abstract：The title compounds (7a～7g) were synthesized from dehydroabietic acid and characterized by spectroscopic methods including HR-MS, 1H- and 13C-NMR. The crystal structure of compound 7g determined by single-crystal X-ray diffractio is of monoclinic system, space group P21 with a = 12.282(3), b = 9.940(2), c = 22.656(5) Å, β = 103.06(3)°, Z = 2, V = 2694.4(10) Å3, Mr = 1182.95, Dc = 1.458 Mg/m3, S = 1.000, μ = 1.649 mm-1, F(000) = 1216, the final R = 0.0791 and wR = 0.1853 for 4098 observed reflections (I > 2σ(I)). The preliminary antibacterial assay showed that compound 7g exhibits significant inhibitory against Bacillus subtilis, Staphylococcus aureus and Methicillin-resistant S. aureus (MRSA) with MIC values of 1.9～7.8 μg/mL.

Key words： dehydroabietic acid benzimidazole sulfonamide crystal structure antibacterial activity

收稿日期: 2019-10-15 出版日期: 2020-08-12

基金资助:This work was supported by the National Natural Science Foundation of China (31770616 and 21601087), the Natural Science Foundation for Colleges and Universities in Jiangsu Province (17KJA220002) and Top-notch Academic Programs Project of Jiangsu Higher Education Institutions (PPZY2015C221). The authors would thank the Modern Analysis and Testing Center, Nanjing Forestry University for NMR test

通讯作者: xumin.cai@njfu.edu.cn E-mail: xumin.cai@njfu.edu.cn

引用本文:

蔡旭敏;李阿良;蔺玉婷;王文燕;王石发;谷文. Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo[d]imidazol-2-yl)benzenesulfonamide Derivatives of Dehydroabietic Acid[J]. 结构化学, 2020, 39(8): 1539-1545.
CAI Xu-Min;LI A-Liang;LIN Yu-Ting;WANG Wen-Yan;WANG Shi-Fa;GU Wen. Synthesis, Crystal Structure and Antibacterial Activity of New N-(1H-benzo[d]imidazol-2-yl)benzenesulfonamide Derivatives of Dehydroabietic Acid. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2020, 39(8): 1539-1545.

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http://manu30.magtech.com.cn/jghx/CN/ 或 http://manu30.magtech.com.cn/jghx/CN/Y2020/V39/I8/1539

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