Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine

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摘要

The title compound 2-(4-chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine (C19H17ClN2) was synthesized and characterized by elemental analysis, 1H NMR, HRMS and single-crystal X-ray diffraction. The crystal of the title compound belongs to orthorhombic system, space group Pnma with a = 11.385(2), b = 12.170(2), c = 11.210(2) Å, V = 1553.2(5) Å3, Z = 4, Dc = 1.321 g/cm3, (Mo-K) = 0.244 mm-1, F(000) = 648, S = 1.309, R = 0.0400 and wR (I > 2(I)) = 0.1065. X-ray diffraction results showed that the molecular structure is highly symmetric and the new-formed N-heterocyclic ring is non-planar. In addition, the biological experiment showed that the title compound showed inhibitory activities against fungi with varied potencies.

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	袁霖
	李中燕
	张敏
	袁先友

关键词 ： perimidine, synthesis, crystal structure, biological activity

Abstract：

Key words： perimidine synthesis crystal structure biological activity

收稿日期: 2016-01-13 出版日期: 2016-08-10

基金资助:

This work was financially supported by the Science and Technology Planning Project of Hunan Province 2015GK3037) and the Scientific Research Fund of Hunan Provincial Education Department (14A058, 13A030)

通讯作者: lizhongyandongdong@126.com E-mail: yuanxianzhangmin@163.com

引用本文:

袁霖;李中燕;张敏;袁先友. Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine[J]. 结构化学, 2016, 35(8): 1181-1185.
YUAN Lin;LI Zhong-Yan;ZHANG Min;YUAN Xian-You. Synthesis, Crystal Structure and Anti-fungal Activity of 2-(4-Chlorophenyl)-1,3-dimethyl-2,3-dihydro-1H-perimidine. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2016, 35(8): 1181-1185.

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http://manu30.magtech.com.cn/jghx/CN/ 或 http://manu30.magtech.com.cn/jghx/CN/Y2016/V35/I8/1181

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