A Novel 3-D Zn(II) Coordination Polymer for Inhibiting the Human Osteosarcoma Cells Growth
张帆;彭昊;尚峥辉;粱杰;茹能
a (Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan 430000, China)
b (Department of Orthopedics, Renmin Hospital of Three Gorges University, Yichang, Hubei 443000, China)
A Novel 3-D Zn(II) Coordination Polymer for Inhibiting the Human Osteosarcoma Cells Growth
ZHANG Fan;PENG Hao;SHANG Zheng-Hui;LIANG Jie;RU Neng
a (Department of Orthopaedics, Renmin Hospital of Wuhan University, Wuhan 430000, China)
b (Department of Orthopedics, Renmin Hospital of Three Gorges University, Yichang, Hubei 443000, China)
A new three-dimensional Zn(II) coordination polymer, namely [Zn4(bpydb)3(tz)2(H2O)2]n (1), has been synthesized by the self-assembly reactions of Zn(NO3)2•6H2O, bpydbH2, Htz and DMF. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional framework structure and is the first example of Zn-containing coordination polymers based on two kinds of ligands bpydbH2 and Htz. It crystallizes in triclinic, space group P with a = 14.9953(12), b = 17.5335(17), c = 20.2381(11) Å, α = 115.225(7), β = 92.329(5), γ = 105.606(8)º, V = 4561.9(7) Å3, Z = 2, F(000) = 1644, Dc = 1.177 Mg/m3, Mr = 1616.76 and μ = 1.098 mm-1. The antitumor activities of compound 1 and its corresponding organic ligands (bpydbH2 and Htz) were investigated for inhibiting human osteosarcoma cells (MG-63 and U-2 OS) growth by MTT assay. It was found that compared with the two ligands, compound 1 exerted rather potent activities against all of these cell lines.
Abstract： A new three-dimensional Zn(II) coordination polymer, namely [Zn4(bpydb)3(tz)2(H2O)2]n (1), has been synthesized by the self-assembly reactions of Zn(NO3)2•6H2O, bpydbH2, Htz and DMF. Single-crystal X-ray structural analysis reveals that compound 1 features a three-dimensional framework structure and is the first example of Zn-containing coordination polymers based on two kinds of ligands bpydbH2 and Htz. It crystallizes in triclinic, space group P with a = 14.9953(12), b = 17.5335(17), c = 20.2381(11) Å, α = 115.225(7), β = 92.329(5), γ = 105.606(8)º, V = 4561.9(7) Å3, Z = 2, F(000) = 1644, Dc = 1.177 Mg/m3, Mr = 1616.76 and μ = 1.098 mm-1. The antitumor activities of compound 1 and its corresponding organic ligands (bpydbH2 and Htz) were investigated for inhibiting human osteosarcoma cells (MG-63 and U-2 OS) growth by MTT assay. It was found that compared with the two ligands, compound 1 exerted rather potent activities against all of these cell lines.
张帆;彭昊;尚峥辉;粱杰;茹能. A Novel 3-D Zn(II) Coordination Polymer for Inhibiting the Human Osteosarcoma Cells Growth[J]. 结构化学, 2016, 35(7): 1019-1023.
ZHANG Fan;PENG Hao;SHANG Zheng-Hui;LIANG Jie;RU Neng. A Novel 3-D Zn(II) Coordination Polymer for Inhibiting the Human Osteosarcoma Cells Growth. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2016, 35(7): 1019-1023.
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2016, Vol. 35 
