Synthesis, Crystal Structure and Antitumor Activity of a New Zn(II) Complex Based on N- Acetyl-L-phenylalanine and 1,10-Phenanthroline

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摘要

A new Zn(II) complex, [Zn(L)2(phen)(H2O)] (1, HL = N-acetyl-L-phenylalanine, phen = 1,10-phenanthroline) has been synthesized and characterized by elemental analysis, IR and X-ray single-crystal diffraction analysis. The Zn(II) complex belongs to monoclinic, space group P21 with a = 12.6749(13), b = 5.5965(6), c = 22.985(2) Å, β = 104.296(2)°, V = 1580.0(3) Å3, Z = 2, Mr = 676.02, Dc = 1.421 µg•m-3, µ = 0.833 mm-1, F(000) = 704, and the final R = 0.0460, wR = 0.0899 for 4422 observed reflections with I > 2σ(I). The molecules form a 1D chained structure by hydrogen bonds. The antitumor activities of Zn(II) complex against human hepatoma SMMC-7721 cells, human lung adenocarcinoma A549 cells and human colon carcinoma WiDr cells have also been investigated.

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	TAI Xi-Shi
	WANG Xin
	YOU Hai-Ying

关键词 ： N-acetyl-L-phenylalanine, Zn(II) complex, synthesis, crystal structure, antitumor activity

Abstract：

Key words： N-acetyl-L-phenylalanine Zn(II) complex synthesis crystal structure antitumor activity

收稿日期: 2015-07-23 出版日期: 2016-04-11

基金资助:

This work was supported by the National Natural Science Foundation of China (No. 21171132), the Project of Shandong Province Higher Educational Science and Technology Program (J14LC01) and Science Foundation of Weifang

通讯作者: taixishi@lzu.edu.cn or taixs@wfu.edu.cn E-mail: taixishi@lzu.edu.cn

引用本文:

TAI Xi-Shi;WANG Xin;YOU Hai-Ying. Synthesis, Crystal Structure and Antitumor Activity of a New Zn(II) Complex Based on N- Acetyl-L-phenylalanine and 1,10-Phenanthroline[J]. 结构化学, 2016, 35(4): 586-590.
台夕市;王欣;游海英. Synthesis, Crystal Structure and Antitumor Activity of a New Zn(II) Complex Based on N- Acetyl-L-phenylalanine and 1,10-Phenanthroline. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2016, 35(4): 586-590.

链接本文:

http://manu30.magtech.com.cn/jghx/CN/ 或 http://manu30.magtech.com.cn/jghx/CN/Y2016/V35/I4/586

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