Syntheses, Structure and Interactions with DNA of Two in situ Generated Palladium (II) Complexes

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摘要 Two new complexes [Pd(L-phe)2·2H2O] (1) and [Pd(4,4΄-dcbpy)(en)·H2O] (2) (L-phe = L-phenylalanine, 4,4΄-dcbpy = 2,2΄-bipyridyl-4,4΄-dicarboxylate, en = ethylenediamine) were synthesized and characterized. L-phenylalanine was in situ formed via the hydrolysis of N-(tert-butoxycarbonyl)-L-phenylalanine, and ethylenediamine came from the in situ reaction of piperazine (pip) under hydrothermal conditions. The single-crystal X-ray structure analyses reveal that the Pd(II) ion constructs a square planer coordination geometry in complexes 1 and 2, respectively. Complex 1 extends into a 2D layered structure via H-bond interactions and complex 2 connects into a 3D network through hydrogen bonds and π-π stacking interactions. The interactions of 1 and 2 with fish sperm DNA (FS-DNA) were examined via UV-Vis absorption spectra and fluorescence spectroscopy. The cleavage reaction for plasmid DNA has been assayed by agarose gel electrophoresis. The results indicate that two complexes interact with DNA and the insertion is the main binding mode.

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	由立新
	李金石
	熊刚
	王淑菊
	孙亚光

关键词 ： crystal structure, Pd(II) complex, in situ reaction, L-phenylalanine, ethylenediamine, 2,2?-bipyridyl-4,4?-dicarboxylate

Abstract：Two new complexes [Pd(L-phe)2·2H2O] (1) and [Pd(4,4΄-dcbpy)(en)·H2O] (2) (L-phe = L-phenylalanine, 4,4΄-dcbpy = 2,2΄-bipyridyl-4,4΄-dicarboxylate, en = ethylenediamine) were synthesized and characterized. L-phenylalanine was in situ formed via the hydrolysis of N-(tert-butoxycarbonyl)-L-phenylalanine, and ethylenediamine came from the in situ reaction of piperazine (pip) under hydrothermal conditions. The single-crystal X-ray structure analyses reveal that the Pd(II) ion constructs a square planer coordination geometry in complexes 1 and 2, respectively. Complex 1 extends into a 2D layered structure via H-bond interactions and complex 2 connects into a 3D network through hydrogen bonds and π-π stacking interactions. The interactions of 1 and 2 with fish sperm DNA (FS-DNA) were examined via UV-Vis absorption spectra and fluorescence spectroscopy. The cleavage reaction for plasmid DNA has been assayed by agarose gel electrophoresis. The results indicate that two complexes interact with DNA and the insertion is the main binding mode.

Key words： crystal structure Pd(II) complex in situ reaction L-phenylalanine ethylenediamine 2,2?-bipyridyl-4,4?-dicarboxylate

收稿日期: 2015-01-19 出版日期: 2015-08-09

基金资助:

This work was conducted in the framework of a project sponsored by the National Natural Science Foundation of
China (No. 21071100) and Program for Liaoning Excellent Talents in University (LJQ2014043

通讯作者: sunyaguang@syuct.edu.cn E-mail: sunyaguang@syuct.edu.cn

引用本文:

由立新;李金石;熊刚;王淑菊;孙亚光. Syntheses, Structure and Interactions with DNA of Two in situ Generated Palladium (II) Complexes[J]. 结构化学, 2015, 34(8): 1238-1246.
YOU Li-Xin;LI Jin-Shi;XIONG Gang;WANG Shu-Ju;SUN Ya-Guang. Syntheses, Structure and Interactions with DNA of Two in situ Generated Palladium (II) Complexes. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2015, 34(8): 1238-1246.

链接本文:

http://manu30.magtech.com.cn/jghx/CN/ 或 http://manu30.magtech.com.cn/jghx/CN/Y2015/V34/I8/1238

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