Synthesis and Crystal Structure of a Dinuclear Cu(II) Complex Based on a Carboxyl-substituted 1H-1,2,3-Triazole and Its DNA Cleavage Activity

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摘要

The novel dinuclear copper complex [Cu2(H2O)2(DMF)2(L)2] (1, H2L = 5-phenyl- 2H-1,2,3- triazole-4-carboxylic acid, DMF = N,N-dimethyl-formamide) has been synthesized and characterized by X-ray single-crystal diffraction. The compound crystallizes in triclinic system, space group P with a = 9.591, b = 10.508, c = 15.515 Å, β = 75.11°, V = 1446.2 Å3, Z = 2, Mr = 683.62, Dc = 1.570 g/cm3, μ = 1.531 mm-1, F(000) = 700, the final R = 0.0404 and wR = 0.1130 for 5327 observed reflections with I > 2σ(I). In each unit of the complex, two Cu2+ ions coordinated with two triazole ligands to form a dimeric [5,6,5] tricyclic structure. The central Cu atom is five-coordinated, and each copper atom shows a square pyramidal geometry. The crystal structure is stabilized by the inversion-related O–H···O hydrogen bond and C–H···O hydrogen bonding interactions to form a layer structure. Fluorescent spectra show an obvious quenching of fluorescence compared with free 1,2,3-triazole ligand. The results of agarose gel electrophoresis indicate that this complex can cleave the plasmid supercoiled DNA within shorter time in the 50-folds excess of ascorbate under physiological conditions, providing a new example in the research for artificial metal nucleic acid enzyme.

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	刘文倩
	周石磊
	范明珠
	潘志权
	陈云峰

关键词 ： 1,2,3-triazole, copper complex, crystal structure, fluorescent property

Abstract：

Key words： 1,2,3-triazole, copper complex crystal structure fluorescent property

收稿日期: 2015-01-13 出版日期: 2015-05-28

基金资助:

This work was supported by the National Natural Science Foundation of China (No. 21002076)
and Wuhan Youth Chenguang Program of Science and Technology (No. 201271031374)

通讯作者: 潘志权 E-mail: 14323793@qq.com

引用本文:

刘文倩;周石磊;范明珠;潘志权;陈云峰. Synthesis and Crystal Structure of a Dinuclear Cu(II) Complex Based on a Carboxyl-substituted 1H-1,2,3-Triazole and Its DNA Cleavage Activity[J]. 结构化学, 2015, 34(6): 917-924.
LIU Wen-Qian;ZHOU Shi-Lei;FAN Ming-Zhu;PAN Zhi-Quan;CHEN Yun-Feng. Synthesis and Crystal Structure of a Dinuclear Cu(II) Complex Based on a Carboxyl-substituted 1H-1,2,3-Triazole and Its DNA Cleavage Activity. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2015, 34(6): 917-924.

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http://manu30.magtech.com.cn/jghx/CN/ 或 http://manu30.magtech.com.cn/jghx/CN/Y2015/V34/I6/917

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