Co<sub>3</sub>O<sub>4</sub>/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum

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摘要 In this paper, we present a novel, reliable and sensitive electrochemical sensor for the determination of paracetamol based on hollow carbon Co3O4 nanosheets/reduced graphene oxide composite (Co3O4/r-GO). The Co3O4/r-GO was prepared via a rapid one-step microwave solvothermal process. Some series of techniques that included scanning electron microscopy, X-ray diffraction and Raman were carried out to characterize the morphology and structure of as-prepared materials. Most importantly, the developed electrochemical sensor exhibited a wide linear range of 0.05 to 900.0 μM and a low detection limit of 14.0 nM (S/N = 3) by using differential pulse voltammetry. Furthermore, the selectivity, repeatability, stability and practical applicability were further studied with satisfactory results.

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	陈华林
	黄启同
	胡世荣
	唐淑丽
	杨浩
	李占明

关键词 ： Co₃O₄ nanosheets, reduced graphene oxide, paracetamol, electrochemical sensor

Abstract：In this paper, we present a novel, reliable and sensitive electrochemical sensor for the determination of paracetamol based on hollow carbon Co3O4 nanosheets/reduced graphene oxide composite (Co3O4/r-GO). The Co3O4/r-GO was prepared via a rapid one-step microwave solvothermal process. Some series of techniques that included scanning electron microscopy, X-ray diffraction and Raman were carried out to characterize the morphology and structure of as-prepared materials. Most importantly, the developed electrochemical sensor exhibited a wide linear range of 0.05 to 900.0 μM and a low detection limit of 14.0 nM (S/N = 3) by using differential pulse voltammetry. Furthermore, the selectivity, repeatability, stability and practical applicability were further studied with satisfactory results.

Key words： Co3O4 nanosheets reduced graphene oxide paracetamol electrochemical sensor

收稿日期: 2019-07-15 出版日期: 2020-06-10

基金资助:This project was supported by the Education Bureau of the Fujian province (No. JAT160302) projects), the Natural Science Foundation of Zhejiang province (No. LQ17C200002), and the Talents’ Start-up Fund of Gannan Medical University (No. QD201825) projects

通讯作者: hushirong6666@163.com E-mail: hushirong6666@163.com

引用本文:

陈华林;黄启同;胡世荣;唐淑丽;杨浩;李占明. Co₃O₄/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum[J]. 结构化学, 2020, 39(6): 1035-1043.
CHEN Hua-Lin;HUANG Qi-Tong;HU Shi-Rong;TANG Shu-Li;YANG Hao;LI Zhan-Ming. Co3O4/reduced Graphene Oxide Composite as An Enhanced Material for Electrochemical Detection of Paracetamol in Human Serum. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2020, 39(6): 1035-1043.

链接本文:

http://manu30.magtech.com.cn/jghx/CN/ 或 http://manu30.magtech.com.cn/jghx/CN/Y2020/V39/I6/1035

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