Syntheses, Crystal Structures and Biological Activity of the Diorganotin 2-(2-(4-Methoxybenzoyl)hydrazono)-3-phenylpropanoic Carboxylate Complexes

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摘要 Diorganotin 2-(2-(4-methoxybenzoyl)hydrazono)-3-phenylpropanoic carboxylate complexes I {[p-CH3O-C6H4O(O)C=N-N=C(PhCH2)COO](n-Bu)2Sn(CH3OH)}2 and II {[p-CH3O-C6H4O(O)C=N- N=C(PhCH2)COO](PhCH2)2Sn(CH3OH)}2 have been synthesized. The complexes have been characterized by IR, 1H, 13C and 119Sn NMR spectra, HRMS, elemental analysis, thermal stability analysis and the crystal structures have been determined by X-ray diffraction. The crystal of complex I belongs to triclinic system, space group P with a = 10.437(2), b = 11.576(3), c = 13.085(3) Å, α = 66.272(2)°, β = 86.920(3)°, γ = 73.367(3)°, Z = 2, V = 1383.3(5) Å3, Dc = 1.381 Mg·m–3, m(MoKα) = 0.959 mm–1, F(000) = 592, R = 0.0233 and wR = 0.0644. The crystal of complex II is of triclinic system, space group P with a = 10.446(1), b = 11.720(1), c = 13.063(2) Å, α = 84.190(1)°, β = 71.610(1)°, γ = 72.624(1)°, Z = 1, V = 1448.3(3) Å3, Dc = 1.475 Mg·m–3, m(MoKα) = 0.925 mm–1, F(000) = 656, R = 0.0169 and wR = 0.0432. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines (NCI-H460, HepG2 and MCF7), and two complexes exhibited good antitumor activity. The interaction between complex I and calf thymus DNA were studied by UV-vis and fluorescence spectroscopy, the interaction of complex I with calf thymus DNA were intercalation.

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	王曼
	余飞
	蒋伍玖
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	张复兴
	邝代治

关键词 ： diorganotin, carboxylate, synthesis, crystal structure, biological activity

Abstract：Diorganotin 2-(2-(4-methoxybenzoyl)hydrazono)-3-phenylpropanoic carboxylate complexes I {[p-CH3O-C6H4O(O)C=N-N=C(PhCH2)COO](n-Bu)2Sn(CH3OH)}2 and II {[p-CH3O-C6H4O(O)C=N- N=C(PhCH2)COO](PhCH2)2Sn(CH3OH)}2 have been synthesized. The complexes have been characterized by IR, 1H, 13C and 119Sn NMR spectra, HRMS, elemental analysis, thermal stability analysis and the crystal structures have been determined by X-ray diffraction. The crystal of complex I belongs to triclinic system, space group P with a = 10.437(2), b = 11.576(3), c = 13.085(3) Å, α = 66.272(2)°, β = 86.920(3)°, γ = 73.367(3)°, Z = 2, V = 1383.3(5) Å3, Dc = 1.381 Mg·m–3, m(MoKα) = 0.959 mm–1, F(000) = 592, R = 0.0233 and wR = 0.0644. The crystal of complex II is of triclinic system, space group P with a = 10.446(1), b = 11.720(1), c = 13.063(2) Å, α = 84.190(1)°, β = 71.610(1)°, γ = 72.624(1)°, Z = 1, V = 1448.3(3) Å3, Dc = 1.475 Mg·m–3, m(MoKα) = 0.925 mm–1, F(000) = 656, R = 0.0169 and wR = 0.0432. In vitro antitumor activities of both complexes were evaluated by MTT against three human cancer cell lines (NCI-H460, HepG2 and MCF7), and two complexes exhibited good antitumor activity. The interaction between complex I and calf thymus DNA were studied by UV-vis and fluorescence spectroscopy, the interaction of complex I with calf thymus DNA were intercalation.

Key words： diorganotin carboxylate synthesis crystal structure biological activity

收稿日期: 2020-01-30 出版日期: 2020-11-09

基金资助:Supported by Hengyang Normal University College Students Scientific and Technological Works Project (No. 167 and 168), Foundation of Key Laboratory of Functional Organometallic Materials, University of Hunan Province (No. GN19K07), Scientific Research Fund of Hunan Provincial Education Department of China (No. 19C0279) and Hengyang Normal University Industrial Supported Project (Nos. HXKJ201908, HXKJ201911, HXKJ201946 and HXKJ201947)

通讯作者: jwj_china@163.com E-mail: jwj_china@163.com

引用本文:

王曼;余飞;蒋伍玖;谭宇星;张复兴;邝代治. Syntheses, Crystal Structures and Biological Activity of the Diorganotin 2-(2-(4-Methoxybenzoyl)hydrazono)-3-phenylpropanoic Carboxylate Complexes[J]. 结构化学, 2020, 39(11): 1965-1972.
WANG Man;YU Fei;JIANG Wu-Jiu;TAN Yu-Xing;ZHANG Fu-Xing;KUANG Dai-Zhi . Syntheses, Crystal Structures and Biological Activity of the Diorganotin 2-(2-(4-Methoxybenzoyl)hydrazono)-3-phenylpropanoic Carboxylate Complexes. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2020, 39(11): 1965-1972.

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