(Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei 443002, China)
Solvent-free Synthesis and Crystal Structure of 2,2΄-Dialkyl Bis(3-methyl-6,7- dihydrobenzofuran-4(5H)-one) Derivatives
(Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, Hubei 443002, China)
A series of 2,2΄-dialkyl bis(3-methyl-6,7-dihydrobenzofuran-4(5H)-one) derivatives was prepared through H2SO4•SiO2 catalyzed condensation reaction under solvent-free conditions as potential anti-tumor agents. All of them were characterized by ESI-MS, IR and NMR spectra. Meanwhile, the single crystal of the target compound (4b), C24H28O4, was also obtained and determined by X-ray crystallography. Crystal data: triclinic system, space group P , a = 8.463(10), b = 9.612(11), c = 13.828(15) Å, α = 74.29(5), β = 80.93(5), γ = 69.90(3)°, V = 1014(2) Å3, Z = 2, F(000) = 408, Dc = 1.246 g/cm3, μ = 0.084 mm−1, R = 0.0883 and wR = 0.2440 for 4616 independent reflections (Rint = 0.1200) and 3490 observed ones (I > 2σ(I)).
This project was supported by the National Natural Science Foundation of China (No. 21602123), China Scholarship Council (No. 201508420062) and Youth Talent Development Foundation of China Three Gorges University
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hny115@126.com
E-mail: hny115@126.com
引用本文:
丁泽鉴;张锋;徐天笑;王文彬;金蕾;黄年玉. 2,2΄-二烷基 双(3-甲基-6,7-二氢苯并呋喃-4(5H)-酮) 衍生物的无溶剂合成及其晶体结构[J]. 结构化学, 2017, 36(7): 1124-1129.
DING Ze-Jian;ZHANG Feng;XU Tian-Xiao;WANG Wen-Bin;JIN Lei;HUANG Nian-Yu. Solvent-free Synthesis and Crystal Structure of 2,2΄-Dialkyl Bis(3-methyl-6,7- dihydrobenzofuran-4(5H)-one) Derivatives. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2017, 36(7): 1124-1129.
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