Synthesis, Crystal Structure and Antifungal Activity of 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole
孙国香;石延霞;翟志文;孙召慧;翁建全;谭成侠;刘幸海;李宝聚
a (School of Chemistry and Chemical Engineering,Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China)
b (College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China)
c (Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100014, China)
Synthesis, Crystal Structure and Antifungal Activity of 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole
SUN Guo-Xiang;SHI Yan-Xia;ZHAI Zhi-Wen;SUN Zhao-Hui;WENG Jian-Quan;TAN Cheng-Xia;LIU Xing-Hai;LI Bao-Ju
a (School of Chemistry and Chemical Engineering,Yancheng Institute of Technology, Yancheng, Jiangsu 224051, China)
b (College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, China)
c (Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100014, China)
The title compound 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole (C14H10FN3OS) was synthesized, and its structure was confirmed by 1H NMR, MS, elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system, space group P21/n with a = 11.541(16), b = 8.226(12), c = 13.683(19) Å, β = 94.872(17)º, V = 1294(3) Å3, Z = 4 and R = 0.0648 for 2198 observed reflections with I > 2σ(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.
Abstract：The title compound 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole (C14H10FN3OS) was synthesized, and its structure was confirmed by 1H NMR, MS, elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system, space group P21/n with a = 11.541(16), b = 8.226(12), c = 13.683(19) Å, β = 94.872(17)º, V = 1294(3) Å3, Z = 4 and R = 0.0648 for 2198 observed reflections with I > 2σ(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.
This work was funded by the Natural Science Foundation of Zhejiang Province (No. LY16C140007) and the program of Science and Technology of Jiangsu Province (BY2014108-14)
通讯作者:
xhliu@zjut.edu.cn
E-mail: xhliu@zjut.edu.cn
引用本文:
孙国香;石延霞;翟志文;孙召慧;翁建全;谭成侠;刘幸海;李宝聚. Synthesis, Crystal Structure and Antifungal Activity of 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole[J]. 结构化学, 2016, 35(12): 1855-1859.
SUN Guo-Xiang;SHI Yan-Xia;ZHAI Zhi-Wen;SUN Zhao-Hui;WENG Jian-Quan;TAN Cheng-Xia;LIU Xing-Hai;LI Bao-Ju. Synthesis, Crystal Structure and Antifungal Activity of 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2016, 35(12): 1855-1859.
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